Cyclobenzaprine: Side Effects, dosage, uses, and more
Cyclobenzaprine belongs to a class of drugs called muscle relaxants. A class of drugs is a group of medications that work in a similar way. This is a drug that isn’t usually considered one of the more common drugs people need to recover from.
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It’s also be effective in treating low back pain, neck pain, and fibromyalgia. Because there is not enough evidence that cyclobenzaprine is effective for long-term use, and because the muscle spasms it is indicated for are generally of short duration, it is typically prescribed for nolonger than two to three weeks. If cyclobenzaprine is being misused, however, the person may continue to take the medication flexeril maximum dose for much longer and may increase their dose too high, which could lead to dangerous side effects and overdose. As mentioned above, there is not a significant difference between Robaxin, Fexmid, Amrix, and other muscle relaxants in terms of efficacy in treating acute low back pain, other musculoskeletal pain, and muscle spasms. However, one drug might be more effective for you than another.
Accordingly, the effects of cyclobenzaprine on both antagonism of the histamine-induced Ca+2 and G-protein effects appear to be mainly a result of the decrease in Emax, which significantly affects the EC50 seen in both assays. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.
Avoid driving or hazardous activity until you know how cyclobenzaprine will affect you. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Adding plans allows you to compare formulary status to other drugs in the same class. Don’t take this medicine for longer than three weeks without talking to your doctor.
The results suggest that cyclobenzaprine is superior to both placebo and clonazepam when added to self-care and education for the management of jaw pain upon awakening. In this study cyclobenzaprine (10mg/d) failed to significantly improve sleep in the short term but this may have been due to the relatively low dose employed. The usual dose is 5–10mg three times daily and treatment for more than 2–3 weeks is not recommended. If you have muscle spasms or muscle pain and plan to take skeletal muscle relaxants, please work with your healthcare provider to find the one that works best for you. Keep in mind that along with medications for short-term alleviation of pain and discomfort, rest and physical therapy can help with long-term pain relief and function.
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Drowsiness is the most commonly reported side effect in studies, occurring in up to 38% (38 out of 100) of people. Avoid or limit the use of alcohol or other sedating medicines while being treated with cyclobenzaprine. Also avoid driving, operating machinery, or other hazardous activities until you know how cyclobenzaprine affects you. Flexeril and Diazepam are both used to treat muscle spasms.
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However, the truth is cyclobenzaprine belongs to a separate class of chemicals known as a muscle relaxant. Rather than activating opioid receptors like other prescription painkillers, Flexeril instead blocks certain nerve impulses that are sent to the brain. Just because cyclobenzaprine isn’t an opioid though doesn’t mean it hasn’t become a substance of abuse.
What is the most important information I should know about Cyclobenzaprine (Flexeril)?
Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Ask your healthcare professional how you should dispose of any medicine you do not use. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Many side effects of SSRIs stop after a few weeks of taking the medication, but if nausea, headache, insomnia, or agitation last for several weeks or becoming intolerable, talk to your healthcare provider about trying another medication (22).
- However, the truth is cyclobenzaprine belongs to a separate class of chemicals known as a muscle relaxant.
- The medication helps control the muscle spasms that result in pain.
- There have been a number of fatalities reported as a result of the Flexeril and alcohol combination that occurred from physical harm caused by over-intoxication.
Given the high affinity of cyclobenzaprine for H1R, it is somewhat surprising that only 30%–40% of patients on cyclobenzaprine experience significant drowsiness and sedative-hypnotic effects. This less-than-expected proportion agrees with effects seen with other first-generation antihistamines, including diphenhydramine, and may be a result of metabolites, which in that case can cause paradoxical stimulation (de Leon and Nikoloff, 2008). In the case of cyclobenzaprine, it is known that dosage, administration, and formulation can also play a role, given the relatively slow biotransformation and accumulation of the agent. Finally, since cyclobenzaprine acts in part via inhibition of NET and also exhibits α2-adrenoreceptor antagonism (Muramatsu et al., 1993), sedative effects may be offset by norepinephrine-mediated stimulation. Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.
Flexeril is the brand name for Cyclobenzaprine, a prescription muscle relaxer that is similar to a class of Antidepressant drugs called Tricyclic Antidepressants. The generic form was first approved in 1977 and is sold in both immediate and extended release versions. Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor.